{
  "fmiVersion": "2.0",
  "modelName": "EnterocyteMucosalBlock.FeMetabolism.Test_Full",
  "modelIdentifier": "EnterocyteMucosalBlock_FeMetabolism_Test_0Full",
  "guid": "{1d15a35b-651d-405a-9abb-d666fd48e57d}",
  "generationTool": "Dymola Version 2025x Refresh 1, 2025-04-11 (Co-simulation using Cvode)",
  "solverTolerance": 1e-8,
  "variables": [
    {
      "name": "TfR_regulation",
      "description": "Uptake from transferrin follows TfR1 in liver and other organs: 1 - yes, 0 - no (Enculescu)",
      "valueReference": 16777216,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [],
      "start": 1
    },
    {
      "name": "local_gain",
      "description": "Strength of the cell&#39;s own iron regulation in every organ: 1 - Enculescu, more - a steeper ferroportin and TfR1 response",
      "valueReference": 16777217,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [],
      "start": 1
    },
    {
      "name": "serum.Liver_in",
      "description": "Fe input from liver",
      "valueReference": 1174405135,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
        },
        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "serum.Spleen_in",
      "description": "Fe input from spleen",
      "valueReference": 1174405136,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
        },
        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "serum.Duodenum_in",
      "description": "Fe input from duodenum",
      "valueReference": 1174405137,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
          "displayFactor": 1,
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        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
        },
        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "serum.OtherOrgans_in",
      "description": "Fe input from other organs",
      "valueReference": 1174405138,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
          "displayFactor": 1,
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        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
        },
        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "serum.Infusion",
      "description": "Fe infusion rate",
      "valueReference": 234881125,
      "causality": "local",
      "variability": "tunable",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
        },
        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "serum.TfR_liver",
      "description": "Transferrin receptors in the liver, relative: 1 = normal",
      "valueReference": 1174405139,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "1",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "1",
          "displayFactor": 1,
          "displayOffset": 0
        }
      ]
    },
    {
      "name": "serum.TfR_otherOrgans",
      "description": "Transferrin receptors in the other organs, relative: 1 = normal",
      "valueReference": 1174405140,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "1",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "1",
          "displayFactor": 1,
          "displayOffset": 0
        }
      ]
    },
    {
      "name": "serum.EPO",
      "description": "Erythropoietin, relative: 1 = normal",
      "valueReference": 1174405141,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": []
    },
    {
      "name": "serum.Liver_out",
      "description": "Fe output to liver",
      "valueReference": 1174405142,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
          "displayFactor": 1,
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        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
        },
        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "serum.BoneMarrow_out",
      "description": "Fe output to bone marrow",
      "valueReference": 1174405143,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
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          "unit": "kg/s",
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        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
        },
        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "serum.Duodenum_out",
      "description": "Fe output to bone duodenum",
      "valueReference": 1174405144,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
        },
        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "serum.OtherOrgans_out",
      "description": "Fe output to other organs",
      "valueReference": 1174405145,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
        },
        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "serum.Fe",
      "description": "Fe amount in serum",
      "valueReference": 33554432,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug",
      "displayFactor": 1000000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg",
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        },
        {
          "unit": "g",
          "displayFactor": 1000,
          "displayOffset": 0
        },
        {
          "unit": "ug",
          "displayFactor": 1000000000,
          "displayOffset": 0
        }
      ],
      "min": 0,
      "nominal": 0.001,
      "start": 1.51304e-9
    },
    {
      "name": "der(serum.Fe)",
      "description": "der(Fe amount in serum)",
      "valueReference": 1124073472,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "kg/s",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ]
    },
    {
      "name": "serum.Fe_input",
      "description": "Fe ammount in serum: input",
      "valueReference": 1174405146,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug.h-1",
      "displayFactor": 3600000000000,
      "displayOffset": 0,
      "unitOptions": [
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        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
        },
        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8,
      "start": 0
    },
    {
      "name": "serum.Fe_output",
      "description": "Fe ammount in serum: output",
      "valueReference": 1174405147,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug.h-1",
      "displayFactor": 3600000000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
          "displayFactor": 1,
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        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "serum.Tf_saturation",
      "description": "Transferrin saturation: serum iron against the capacity th, 1 = full",
      "valueReference": 1711276060,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "1",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "1",
          "displayFactor": 1,
          "displayOffset": 0
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      ]
    },
    {
      "name": "serum.th",
      "description": "Threshold serum iron value (k26), 2.08/3.00",
      "valueReference": 16777218,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "ug",
      "displayFactor": 1000000000,
      "displayOffset": 0,
      "unitOptions": [
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          "unit": "kg",
          "displayFactor": 1,
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        {
          "unit": "g",
          "displayFactor": 1000,
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        {
          "unit": "ug",
          "displayFactor": 1000000000,
          "displayOffset": 0
        }
      ],
      "min": 0,
      "nominal": 0.001,
      "start": 2.687e-9
    },
    {
      "name": "serum.v_liv_1",
      "description": "Low liver iron uptake (k4), 2.78/9.81",
      "valueReference": 16777219,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "h-1",
      "displayFactor": 3600,
      "displayOffset": 0,
      "unitOptions": [
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          "unit": "Hz",
          "displayFactor": 1,
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        {
          "unit": "1/min",
          "displayFactor": 60,
          "displayOffset": 0
        },
        {
          "unit": "h-1",
          "displayFactor": 3600,
          "displayOffset": 0
        }
      ],
      "start": 0.0011001944444444444
    },
    {
      "name": "serum.v_liv_2",
      "description": "High liver iron uptake (k45)",
      "valueReference": 16777220,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "h-1",
      "displayFactor": 3600,
      "displayOffset": 0,
      "unitOptions": [
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        {
          "unit": "1/min",
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        {
          "unit": "h-1",
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          "displayOffset": 0
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      ],
      "start": 0.003994722222222222
    },
    {
      "name": "serum.v_bm",
      "description": "Bone marrow uptake rate (k5), 2.66/4.16",
      "valueReference": 16777221,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "h-1",
      "displayFactor": 3600,
      "displayOffset": 0,
      "unitOptions": [
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        {
          "unit": "1/min",
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        {
          "unit": "h-1",
          "displayFactor": 3600,
          "displayOffset": 0
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      ],
      "start": 0.0007848888888888889
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    {
      "name": "serum.EPO_regulation",
      "description": "Erythropoiesis regulated by erythropoietin: 1 - yes, 0 - no (Enculescu)",
      "valueReference": 16777222,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "1",
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      ],
      "start": 1
    },
    {
      "name": "serum.K_bm",
      "description": "Half-saturation of the marrow&#39;s iron uptake, in units of the normal serum iron",
      "valueReference": 16777223,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "1",
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          "displayOffset": 0
        }
      ],
      "start": 0.5
    },
    {
      "name": "serum.Fe_normal",
      "description": "Normal (steady-state) serum iron",
      "valueReference": 16777224,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "ug",
      "displayFactor": 1000000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg",
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        },
        {
          "unit": "g",
          "displayFactor": 1000,
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        {
          "unit": "ug",
          "displayFactor": 1000000000,
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      ],
      "min": 0,
      "nominal": 0.001,
      "start": 1.5130432000000002e-9
    },
    {
      "name": "serum.v_duo",
      "description": "Duodenal uptake rate from blood (k6), 0.6/1.3",
      "valueReference": 16777225,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "h-1",
      "displayFactor": 3600,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "Hz",
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        {
          "unit": "1/min",
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        },
        {
          "unit": "h-1",
          "displayFactor": 3600,
          "displayOffset": 0
        }
      ],
      "start": 0.00019579166666666665
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    {
      "name": "serum.v_res",
      "description": "Other organs uptake rate (k34), 5.4/10.0",
      "valueReference": 16777226,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "h-1",
      "displayFactor": 3600,
      "displayOffset": 0,
      "unitOptions": [
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          "unit": "Hz",
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        {
          "unit": "1/min",
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        {
          "unit": "h-1",
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          "displayOffset": 0
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      ],
      "start": 0.001755722222222222
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    {
      "name": "serum.Fe_regulation",
      "description": "Fe regulation: 1 - auto, 0 - manual",
      "valueReference": 16777227,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [],
      "start": 1
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    {
      "name": "serum.Fe_manual",
      "valueReference": 16777228,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "ug",
      "displayFactor": 1000000000,
      "displayOffset": 0,
      "unitOptions": [
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          "unit": "kg",
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        {
          "unit": "g",
          "displayFactor": 1000,
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        {
          "unit": "ug",
          "displayFactor": 1000000000,
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        }
      ],
      "min": 0,
      "nominal": 0.001,
      "start": 1.51304e-9
    },
    {
      "name": "serum.Fe_regulation_switcher",
      "valueReference": 100663296,
      "causality": "local",
      "variability": "tunable",
      "type": "real",
      "unit": "1",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "1",
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      ]
    },
    {
      "name": "serum.tau_manual",
      "description": "How fast serum iron reaches the hand-set level in manual mode",
      "valueReference": 16777229,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "min",
      "displayFactor": 0.016666666666666666,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "s",
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        },
        {
          "unit": "min",
          "displayFactor": 0.016666666666666666,
          "displayOffset": 0
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      ],
      "nominal": 60,
      "start": 600
    },
    {
      "name": "liver.Serum_in",
      "description": "Fe input from serum",
      "valueReference": 1174405142,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
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          "unit": "kg/s",
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        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
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        },
        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "liver.Serum_out",
      "description": "Fe output to serum",
      "valueReference": 1174405135,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
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          "unit": "kg/s",
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        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
        },
        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
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      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "liver.hep",
      "description": "Hepcidin",
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      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "g",
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      "displayOffset": 0,
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          "unit": "g",
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          "unit": "kg",
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        {
          "unit": "g",
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          "unit": "ug",
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      "min": 0,
      "nominal": 0.001
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    {
      "name": "liver.Fe",
      "description": "Fe amount in liver",
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      "variability": "continuous",
      "type": "real",
      "unit": "ug",
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          "unit": "kg",
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          "unit": "g",
          "displayFactor": 1000,
          "displayOffset": 0
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          "unit": "ug",
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      "nominal": 0.001
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    {
      "name": "der(liver.Fe)",
      "description": "der(Fe amount in liver)",
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      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "kg/s",
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      "displayOffset": 0,
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          "unit": "kg/s",
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          "unit": "mg/min",
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          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
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          "unit": "ug/h",
          "displayFactor": 3600000000000,
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    {
      "name": "liver.FPN",
      "description": "FPN amount in liver (s12)",
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      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug",
      "displayFactor": 1000000000,
      "displayOffset": 0,
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          "unit": "kg",
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          "displayOffset": 0
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        {
          "unit": "g",
          "displayFactor": 1000,
          "displayOffset": 0
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        {
          "unit": "ug",
          "displayFactor": 1000000000,
          "displayOffset": 0
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      ],
      "min": 0,
      "nominal": 0.001,
      "start": 1.00036e-9
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    {
      "name": "der(liver.FPN)",
      "description": "der(FPN amount in liver (s12))",
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      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "kg/s",
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      "displayOffset": 0,
      "unitOptions": [
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          "unit": "kg/s",
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        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
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          "unit": "ug/h",
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      "name": "liver.FPN_mRNA",
      "description": "FPN mRNA amount in liver (s7)",
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      "variability": "continuous",
      "type": "real",
      "unit": "ug",
      "displayFactor": 1000000000,
      "displayOffset": 0,
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          "unit": "kg",
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        {
          "unit": "g",
          "displayFactor": 1000,
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        {
          "unit": "ug",
          "displayFactor": 1000000000,
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      "min": 0,
      "nominal": 0.001
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      "name": "der(liver.FPN_mRNA)",
      "description": "der(FPN mRNA amount in liver (s7))",
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      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "kg/s",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
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          "unit": "ug/h",
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      "name": "liver.Fe_max",
      "description": "Threshold value liver iron export (k43), 100.0/159.0",
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      "variability": "tunable",
      "type": "real",
      "unit": "ug",
      "displayFactor": 1000000000,
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          "unit": "kg",
          "displayFactor": 1,
          "displayOffset": 0
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        {
          "unit": "g",
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        {
          "unit": "ug",
          "displayFactor": 1000000000,
          "displayOffset": 0
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      ],
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      "nominal": 0.001,
      "start": 1.1955e-7
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    {
      "name": "liver.u",
      "description": "Liver iron export rate (k1), 0.05/0.19",
      "valueReference": 16777231,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1/(ug.h)",
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          "unit": "1/(kg.s)",
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          "displayOffset": 0
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          "unit": "1/(ug.h)",
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      "name": "liver.FPN_synthesis",
      "description": "FPN synthesis",
      "valueReference": 1174405149,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
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        {
          "unit": "kg/s",
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          "displayOffset": 0
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        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
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          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
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          "unit": "ug/h",
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      "nominal": 1.6666666666666667e-8
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    {
      "name": "liver.FPN_degradation",
      "description": "FPN degradation",
      "valueReference": 1174405150,
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      "variability": "continuous",
      "type": "real",
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      "displayFactor": 60000000,
      "displayOffset": 0,
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          "unit": "kg/s",
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          "unit": "mg/min",
          "displayFactor": 60000000,
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          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
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          "unit": "ug/h",
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      "nominal": 1.6666666666666667e-8
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      "name": "liver.k_synth",
      "description": "Fpnliv synthesis rate (k28), 0.07/0.14",
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      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "h-1",
      "displayFactor": 3600,
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          "unit": "Hz",
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          "unit": "1/min",
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          "unit": "h-1",
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      "start": 0.00003602777777777778
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      "name": "liver.k_deg",
      "description": "Fpnliv degradation rate (k12), 0.01/0.06",
      "valueReference": 16777233,
      "causality": "parameter",
      "variability": "tunable",
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      "unit": "h-1",
      "displayFactor": 3600,
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          "unit": "Hz",
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          "unit": "1/min",
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          "unit": "h-1",
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          "displayOffset": 0
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      "start": 0.00001537861111111111
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      "name": "liver.k_Fe",
      "description": "Constant Fpn_liv production (k17), 0.002/0.006",
      "valueReference": 16777234,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1/ug",
      "displayFactor": 1e-9,
      "displayOffset": 0,
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        {
          "unit": "1/kg",
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          "displayOffset": 0
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          "unit": "1/ug",
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    {
      "name": "liver.local_gain",
      "description": "Strength of the cell&#39;s own iron regulation (IRP/IRE), both ferroportin and TfR1: 1 - Enculescu",
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      "causality": "local",
      "variability": "tunable",
      "type": "real",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": []
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      "name": "liver.k_hep",
      "description": "Constant Fpnliv degradation (k13), 2.11/12.93",
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      "variability": "tunable",
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      "unit": "1/ug",
      "displayFactor": 1e-9,
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        {
          "unit": "1/kg",
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          "displayOffset": 0
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          "unit": "1/ug",
          "displayFactor": 1e-9,
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      ],
      "start": 2574300000
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    {
      "name": "liver.FPN_mRNA_synthesis",
      "description": "FPN synthesis",
      "valueReference": 1174405151,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
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          "unit": "kg/s",
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          "unit": "mg/min",
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          "unit": "ug.h-1",
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          "unit": "ug/h",
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      ],
      "nominal": 1.6666666666666667e-8
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    {
      "name": "liver.FPN_mRNA_degradation",
      "description": "FPN degradation",
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      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
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        {
          "unit": "kg/s",
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          "unit": "mg/min",
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          "unit": "ug.h-1",
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          "unit": "ug/h",
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      "name": "liver.K_mRNA",
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          "unit": "kg/s",
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        {
          "unit": "mg/min",
          "displayFactor": 60000000,
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          "unit": "ug.h-1",
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          "unit": "ug/h",
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      ],
      "nominal": 1.6666666666666667e-8,
      "start": 2.777777777777778e-13
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      "name": "liver.K1_mRNA",
      "description": "Constant Fpn_liv_mRNA production (k24), 28.0/32.5",
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      "causality": "parameter",
      "variability": "tunable",
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      "unit": "1",
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      "name": "liver.K2_mRNA",
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      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "ug",
      "displayFactor": 1000000000,
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          "unit": "kg",
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          "unit": "g",
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          "unit": "ug",
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      "start": 1.2836000000000001e-12
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      "variability": "tunable",
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      "unitOptions": [
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          "unit": "1/min",
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          "unit": "h-1",
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      "start": 0.00030113888888888893
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      "name": "liver.TfR",
      "description": "Transferrin receptors (TfR1), relative: 1 = normal",
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      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "1",
      "displayFactor": 1,
      "displayOffset": 0,
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      "name": "liver.TfR_regulation",
      "description": "Uptake from transferrin follows TfR1: 1 - yes, 0 - no (Enculescu)",
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      "variability": "tunable",
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      "name": "liver.tau_TfR",
      "description": "Time constant of TfR1",
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      "unit": "min",
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          "unit": "s",
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          "unit": "min",
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      "name": "liver.TfR_max",
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      "name": "liver.Fe_start",
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      "causality": "local",
      "variability": "fixed",
      "type": "real",
      "unit": "ug",
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          "unit": "kg",
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          "unit": "g",
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        {
          "unit": "ug",
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      ],
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      "nominal": 0.001,
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      "name": "liver.TfR_target",
      "description": "TfR1 the cell&#39;s iron asks for (IRP/IRE): the inverse of ferroportin&#39;s (1 + k_Fe*Fe), 1 = normal",
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      "variability": "continuous",
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    {
      "name": "liver.TfR_cell",
      "description": "TfR1 the cell has, relative; with TfR_regulation = 0 it is kept but does not act",
      "valueReference": 33554436,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
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      "unitOptions": []
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    {
      "name": "der(liver.TfR_cell)",
      "description": "der(TfR1 the cell has, relative; with TfR_regulation = 0 it is kept but does not act)",
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      "variability": "continuous",
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    {
      "name": "spleen.BoneMarrow_in",
      "description": "Fe input from bone marrow",
      "valueReference": 1174405154,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
          "displayFactor": 60000000,
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
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        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
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      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "spleen.RBC_in",
      "description": "Fe input from RBC",
      "valueReference": 1174405155,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
          "displayFactor": 60000000,
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
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        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
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      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "spleen.Serum_out",
      "description": "Fe output to serum",
      "valueReference": 1174405136,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
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          "unit": "kg/s",
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        {
          "unit": "mg/min",
          "displayFactor": 60000000,
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
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        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
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      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "spleen.hep",
      "description": "Hepcidin",
      "valueReference": 33554449,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "g",
      "displayFactor": 1000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg",
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        {
          "unit": "g",
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        {
          "unit": "ug",
          "displayFactor": 1000000000,
          "displayOffset": 0
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      ],
      "min": 0,
      "nominal": 0.001
    },
    {
      "name": "spleen.il6",
      "description": "IL6",
      "valueReference": 33554450,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "g",
      "displayFactor": 1000,
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    {
      "name": "spleen.Fe",
      "description": "Fe amount in spleen (s5)",
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      "variability": "continuous",
      "type": "real",
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      ],
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    {
      "name": "der(spleen.Fe)",
      "description": "der(Fe amount in spleen (s5))",
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      "variability": "continuous",
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      "unit": "kg/s",
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          "unit": "ug.h-1",
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    {
      "name": "spleen.FPN",
      "description": "FPN amount in spleen (s14)",
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      "variability": "continuous",
      "type": "real",
      "unit": "ug",
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      "unitOptions": [
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          "unit": "g",
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      ],
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    {
      "name": "der(spleen.FPN)",
      "description": "der(FPN amount in spleen (s14))",
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      "variability": "continuous",
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      "unit": "kg/s",
      "displayFactor": 1,
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      "unitOptions": [
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          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
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        {
          "unit": "ug/h",
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    {
      "name": "spleen.FPN_mRNA",
      "description": "FPN mRNA amount in spleen (s9)",
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      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug",
      "displayFactor": 1000000000,
      "displayOffset": 0,
      "unitOptions": [
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          "unit": "g",
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        {
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      ],
      "min": 0,
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    {
      "name": "der(spleen.FPN_mRNA)",
      "description": "der(FPN mRNA amount in spleen (s9))",
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      "variability": "continuous",
      "type": "real",
      "unit": "kg/s",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
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    {
      "name": "spleen.Fe_max",
      "description": "Threshold value spleen iron export (k44), 57.0/95.0",
      "valueReference": 16777242,
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      "unit": "ug",
      "displayFactor": 1000000000,
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        {
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      ],
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      "nominal": 0.001,
      "start": 8.8216e-8
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    {
      "name": "spleen.u",
      "description": "Spleen export rate (k3), 0.21/0.36",
      "valueReference": 16777243,
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      "variability": "tunable",
      "type": "real",
      "unit": "1/(ug.h)",
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      ],
      "start": 66950
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    {
      "name": "spleen.Fe_input",
      "description": "Fe amount in spleen: total input",
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      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug.h-1",
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      "unitOptions": [
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        {
          "unit": "mg/min",
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          "unit": "ug.h-1",
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    {
      "name": "spleen.Fe_output",
      "description": "Fe amount in spleen: total output",
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        {
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    {
      "name": "spleen.FPN_synthesis",
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      "name": "spleen.FPN_degradation",
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      "unit": "mg/min",
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    {
      "name": "spleen.k_Fe",
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      "unit": "1/ug",
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    {
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      "unit": "mg/min",
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      "nominal": 1.6666666666666667e-8
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      "name": "duodenum.Serum_out",
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        {
          "unit": "mg/min",
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          "unit": "ug.h-1",
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      ],
      "nominal": 1.6666666666666667e-8
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    {
      "name": "duodenum.FeGrowthRate",
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      "type": "real",
      "unit": "1/min",
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    {
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      "type": "real",
      "unit": "g",
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      "min": 0,
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    {
      "name": "duodenum.il6",
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      ],
      "min": 0,
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    {
      "name": "duodenum.Fe",
      "description": "Fe amount in duodenum (s4)",
      "valueReference": 33554440,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
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      "displayFactor": 1000000000,
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      "min": 0,
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      "start": 2.97118e-9
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    {
      "name": "der(duodenum.Fe)",
      "description": "der(Fe amount in duodenum (s4))",
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      "variability": "continuous",
      "type": "real",
      "unit": "kg/s",
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        {
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          "unit": "ug.h-1",
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      ]
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    {
      "name": "duodenum.FPN",
      "description": "Fpn amount in duodenum (s13)",
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      "variability": "continuous",
      "type": "real",
      "unit": "ug",
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      ],
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      "nominal": 0.001,
      "start": 1.00017e-9
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    {
      "name": "der(duodenum.FPN)",
      "description": "der(Fpn amount in duodenum (s13))",
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      "variability": "continuous",
      "type": "real",
      "unit": "kg/s",
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          "unit": "ug.h-1",
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      ]
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    {
      "name": "duodenum.FPN_mRNA",
      "description": "Fpn mRNA amount in duodenum (s8)",
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      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug",
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      "displayOffset": 0,
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      ],
      "min": 0,
      "nominal": 0.001,
      "start": 9.22424e-10
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    {
      "name": "der(duodenum.FPN_mRNA)",
      "description": "der(Fpn mRNA amount in duodenum (s8))",
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      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "kg/s",
      "displayFactor": 1,
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      "unitOptions": [
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          "unit": "kg/s",
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        {
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          "unit": "ug.h-1",
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    {
      "name": "duodenum.u",
      "description": "Duodenal export rate (k2), 0.66/1.38",
      "valueReference": 16777252,
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      ],
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    {
      "name": "duodenum.Fe_intake",
      "description": "Fe intake from food",
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      "causality": "local",
      "variability": "tunable",
      "type": "real",
      "unit": "mg/min",
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      ],
      "nominal": 1.6666666666666667e-8
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    {
      "name": "duodenum.v_max",
      "description": "Maximal duodenal uptake from food (SI. Eq.14)",
      "valueReference": 16777253,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
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          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
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          "unit": "ug/h",
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      ],
      "nominal": 1.6666666666666667e-8,
      "start": 2.7388888888888888e-12
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    {
      "name": "duodenum.K_sat",
      "description": "Saturation parameter duodenal uptake, corresponds to k11",
      "valueReference": 16777254,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
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      "unitOptions": [
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        {
          "unit": "mg/min",
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          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
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          "unit": "ug/h",
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        }
      ],
      "nominal": 1.6666666666666667e-8,
      "start": 4.9261111111111115e-11
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    {
      "name": "duodenum.Fe_absorption",
      "description": "Fe input to duodenum from intestines, prev:in_1",
      "valueReference": 1174405162,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
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        {
          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
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          "unit": "ug/h",
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      ],
      "nominal": 1.6666666666666667e-8
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    {
      "name": "duodenum.unregulated_absorption",
      "valueReference": 16777255,
      "causality": "parameter",
      "variability": "tunable",
      "type": "boolean",
      "displayFactor": 1,
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    {
      "name": "duodenum.malabsorption",
      "description": "iron malabsorption coefficient: <0;1>; 0 = no absorption, 1 = physiologic",
      "valueReference": 16777256,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1",
      "displayFactor": 1,
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      "unitOptions": [
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      ],
      "start": 1
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    {
      "name": "duodenum.K_absorption",
      "valueReference": 16777257,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "ug",
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      "unitOptions": [
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          "unit": "g",
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        {
          "unit": "ug",
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      ],
      "min": 0,
      "nominal": 0.001,
      "start": 1e-9
    },
    {
      "name": "duodenum.Fe_loss",
      "description": "Fe output from duodenum to intestines (Fe loss), prev:out_2",
      "valueReference": 1174405163,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
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      "unitOptions": [
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          "unit": "kg/s",
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        {
          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
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        {
          "unit": "ug/h",
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      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "duodenum.v_lost",
      "description": "Iron lost rate duodenum (k48), 0.001/0.320",
      "valueReference": 16777258,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1/min",
      "displayFactor": 60,
      "displayOffset": 0,
      "unitOptions": [
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          "unit": "1/min",
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      ],
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    {
      "name": "duodenum.Fe_input",
      "description": "Fe amount in duodenum: total input",
      "valueReference": 1711276076,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug.h-1",
      "displayFactor": 3600000000000,
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        {
          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
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      ],
      "nominal": 1.6666666666666667e-8
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    {
      "name": "duodenum.Fe_output",
      "description": "Fe amount in duodenum: total output",
      "valueReference": 1711276077,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug.h-1",
      "displayFactor": 3600000000000,
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        {
          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
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          "unit": "ug/h",
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      ],
      "nominal": 1.6666666666666667e-8
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    {
      "name": "duodenum.Fe_stool",
      "description": "Fe leaving with the stool: food iron not absorbed plus shed enterocytes",
      "valueReference": 1711276078,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug.h-1",
      "displayFactor": 3600000000000,
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      "unitOptions": [
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        {
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
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      ],
      "nominal": 1.6666666666666667e-8
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    {
      "name": "duodenum.FPN_synthesis",
      "description": "FPN synthesis",
      "valueReference": 1174405167,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
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        {
          "unit": "mg/min",
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          "unit": "ug.h-1",
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      ],
      "nominal": 1.6666666666666667e-8
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    {
      "name": "duodenum.FPN_degradation",
      "description": "FPN degradation",
      "valueReference": 1174405168,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
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        {
          "unit": "mg/min",
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          "unit": "ug.h-1",
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      ],
      "nominal": 1.6666666666666667e-8
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    {
      "name": "duodenum.k_synth",
      "description": "Fpnduo synthesis rate (k29), 0.01/0.25",
      "valueReference": 16777259,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "h-1",
      "displayFactor": 3600,
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      "unitOptions": [
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        {
          "unit": "1/min",
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      "start": 0.000008416388888888889
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    {
      "name": "duodenum.k_deg",
      "description": "Fpnduo degradation rate (k12*k15, k15 = 0.3815), 0.0056/0.147",
      "valueReference": 16777260,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "h-1",
      "displayFactor": 3600,
      "displayOffset": 0,
      "unitOptions": [
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      ],
      "start": 0.000005866940138888889
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    {
      "name": "duodenum.k_Fe",
      "description": "Constant Fpn_duo production (k46), 0.06/0.49",
      "valueReference": 16777261,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1/ug",
      "displayFactor": 1e-9,
      "displayOffset": 0,
      "unitOptions": [
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          "unit": "1/ug",
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      "start": 160070000
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    {
      "name": "duodenum.local_gain",
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      "valueReference": 100663303,
      "causality": "local",
      "variability": "tunable",
      "type": "real",
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    {
      "name": "duodenum.Fe_start",
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      "causality": "parameter",
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      "displayFactor": 1000000000,
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      "unitOptions": [
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        {
          "unit": "g",
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        {
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      "min": 0,
      "nominal": 0.001,
      "start": 2.97118e-9
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    {
      "name": "duodenum.k_hep",
      "description": "Constant Fpnduo degradation (k13*k16, k16 = 0.55631), 0.78/4.16",
      "valueReference": 16777263,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1/ug",
      "displayFactor": 1e-9,
      "displayOffset": 0,
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      "start": 1432108833
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    {
      "name": "duodenum.FPN_mRNA_synthesis",
      "description": "FPN synthesis",
      "valueReference": 1174405169,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
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        {
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        {
          "unit": "ug.h-1",
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      ],
      "nominal": 1.6666666666666667e-8
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    {
      "name": "duodenum.FPN_mRNA_degradation",
      "description": "FPN degradation",
      "valueReference": 1174405170,
      "causality": "local",
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      "type": "real",
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      "displayFactor": 60000000,
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      ],
      "nominal": 1.6666666666666667e-8
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    {
      "name": "duodenum.K_mRNA",
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      "unit": "mg/min",
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          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
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        {
          "unit": "ug/h",
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      ],
      "nominal": 1.6666666666666667e-8,
      "start": 2.777777777777778e-13
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    {
      "name": "duodenum.K1_mRNA",
      "description": "Constant Fpn_duo_mRNA production (k35*K_liv_1, k35 = 0.020001), 0.56/0.79",
      "valueReference": 16777265,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1",
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      "unitOptions": [
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      ],
      "start": 0.61323066
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    {
      "name": "duodenum.K2_mRNA",
      "description": "Constant FpnmRNA production (k41), 3.0e-4/2.0e-3",
      "valueReference": 16777266,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "ug",
      "displayFactor": 1000000000,
      "displayOffset": 0,
      "unitOptions": [
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        {
          "unit": "g",
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        {
          "unit": "ug",
          "displayFactor": 1000000000,
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      ],
      "min": 0,
      "nominal": 0.001,
      "start": 1.2836000000000001e-12
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    {
      "name": "duodenum.k_mRNA_deg",
      "description": "FpnmRNA degradation rate (k25), 1.02/1.20",
      "valueReference": 16777267,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
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      "name": "otherOrgans.Fe",
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      "name": "der(otherOrgans.Fe)",
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      "name": "otherOrgans.FPN_mRNA",
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      "name": "otherOrgans.u",
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      "name": "otherOrgans.u_lost",
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      "name": "otherOrgans.FPN_mRNA_degradation",
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      "min": 0,
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      "start": 1.2836000000000001e-12
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      "start": 0.00030113888888888893
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    {
      "name": "otherOrgans.TfR",
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      "name": "otherOrgans.TfR_regulation",
      "description": "Uptake from transferrin follows TfR1: 1 - yes, 0 - no (Enculescu)",
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      "variability": "tunable",
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      "name": "otherOrgans.tau_TfR",
      "description": "Time constant of TfR1",
      "valueReference": 16777280,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "min",
      "displayFactor": 0.016666666666666666,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "s",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "min",
          "displayFactor": 0.016666666666666666,
          "displayOffset": 0
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      ],
      "nominal": 60,
      "start": 43200
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    {
      "name": "otherOrgans.TfR_max",
      "description": "Upper limit of TfR1, relative; only the rise above 1 saturates towards it",
      "valueReference": 16777281,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [],
      "start": 2
    },
    {
      "name": "otherOrgans.Fe_start",
      "description": "Iron at the start (steady state), where TfR1 = 1",
      "valueReference": 100663306,
      "causality": "local",
      "variability": "fixed",
      "type": "real",
      "unit": "ug",
      "displayFactor": 1000000000,
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          "unit": "kg",
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        {
          "unit": "g",
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        {
          "unit": "ug",
          "displayFactor": 1000000000,
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      ],
      "min": 0,
      "nominal": 0.001,
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    {
      "name": "otherOrgans.TfR_target",
      "description": "TfR1 the cell&#39;s iron asks for (IRP/IRE): the inverse of ferroportin&#39;s (1 + k_Fe*Fe), 1 = normal",
      "valueReference": 1174405177,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": []
    },
    {
      "name": "otherOrgans.TfR_cell",
      "description": "TfR1 the cell has, relative; with TfR_regulation = 0 it is kept but does not act",
      "valueReference": 33554446,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
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      "displayOffset": 0,
      "unitOptions": []
    },
    {
      "name": "der(otherOrgans.TfR_cell)",
      "description": "der(TfR1 the cell has, relative; with TfR_regulation = 0 it is kept but does not act)",
      "valueReference": 1124073486,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "displayFactor": 1,
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    {
      "name": "boneMarrow.Serum_in",
      "description": "Fe input from serum",
      "valueReference": 1174405143,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
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          "unit": "kg/s",
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        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "boneMarrow.RBC_out",
      "description": "Fe output to RBC",
      "valueReference": 1174405178,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
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          "unit": "kg/s",
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        {
          "unit": "mg/min",
          "displayFactor": 60000000,
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
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        {
          "unit": "ug/h",
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        }
      ],
      "nominal": 1.6666666666666667e-8
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    {
      "name": "boneMarrow.Spleen_out",
      "description": "Fe output to spleen",
      "valueReference": 1174405154,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
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        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
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      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "boneMarrow.Fe",
      "description": "Fe ammount in bones (s3)",
      "valueReference": 33554447,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug",
      "displayFactor": 1000000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg",
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        {
          "unit": "g",
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        {
          "unit": "ug",
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      ],
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    {
      "name": "der(boneMarrow.Fe)",
      "description": "der(Fe ammount in bones (s3))",
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      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "kg/s",
      "displayFactor": 1,
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      "unitOptions": [
        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
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        {
          "unit": "ug/h",
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      ]
    },
    {
      "name": "boneMarrow.Fe_input",
      "description": "Fe ammount in bones: input",
      "valueReference": 1174405143,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug.h-1",
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        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
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        {
          "unit": "ug/h",
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        }
      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "boneMarrow.Fe_output",
      "description": "Fe ammount in bones: output",
      "valueReference": 1174405179,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug.h-1",
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      "displayOffset": 0,
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        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
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      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "boneMarrow.v_RBC",
      "description": "RBC uptake rate (k8), 0.055/0.075",
      "valueReference": 16777282,
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      "unitOptions": [
        {
          "unit": "Hz",
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        {
          "unit": "1/min",
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        {
          "unit": "h-1",
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      ],
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    {
      "name": "boneMarrow.v_spl_2",
      "description": "Spleen iron uptake rate from bones (k7), 0.008/0.019",
      "valueReference": 16777283,
      "causality": "parameter",
      "variability": "tunable",
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          "unit": "Hz",
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        {
          "unit": "1/min",
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        {
          "unit": "h-1",
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      ],
      "start": 0.000002689361111111111
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    {
      "name": "rBC.BoneMarrow_in",
      "description": "Fe input from bone marrow",
      "valueReference": 1174405178,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
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        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
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          "unit": "ug/h",
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      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "rBC.Transfusion",
      "description": "transfusion rate",
      "valueReference": 234881122,
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      "variability": "tunable",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
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      "unitOptions": [
        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
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        {
          "unit": "ug/h",
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      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "rBC.Bleeding",
      "description": "bleeding rate",
      "valueReference": 234881123,
      "causality": "local",
      "variability": "tunable",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
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        {
          "unit": "ug/h",
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      ],
      "nominal": 1.6666666666666667e-8
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    {
      "name": "rBC.Spleen_out",
      "description": "Fe output to spleen",
      "valueReference": 1174405155,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
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        {
          "unit": "ug/h",
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      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "rBC.Fe",
      "description": "Fe amount in red blood cells (s6)",
      "valueReference": 33554448,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug",
      "displayFactor": 1000000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg",
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        {
          "unit": "g",
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        {
          "unit": "ug",
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      ],
      "min": 0,
      "nominal": 0.001,
      "start": 0.0000010167233
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    {
      "name": "der(rBC.Fe)",
      "description": "der(Fe amount in red blood cells (s6))",
      "valueReference": 1124073488,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "kg/s",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
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        {
          "unit": "ug/h",
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      ]
    },
    {
      "name": "rBC.Fe_input",
      "description": "Fe ammount in bones: input",
      "valueReference": 1174405180,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug.h-1",
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        {
          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
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          "unit": "ug/h",
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      ],
      "nominal": 1.6666666666666667e-8
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    {
      "name": "rBC.Fe_output",
      "description": "Fe ammount in bones: output",
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      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug.h-1",
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      "unitOptions": [
        {
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        {
          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
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        {
          "unit": "ug/h",
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      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "rBC.v_spl_1",
      "description": "Spleen iron uptake rate from RBC (k10), 0.002 = value for trace exp., 0.004/0.005",
      "valueReference": 16777284,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "h-1",
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      "unitOptions": [
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        {
          "unit": "1/min",
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        {
          "unit": "h-1",
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      ],
      "start": 0.0000010009722222222221
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    {
      "name": "rBC.blood_drawn",
      "description": "Blood drawn so far, all draws together, each as a share of the blood there was (the application adds 0.1 per press)",
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      "type": "real",
      "unit": "1",
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      "unitOptions": [
        {
          "unit": "1",
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      ],
      "start": 0
    },
    {
      "name": "rBC.blood_applied",
      "description": "Draws already taken from Fe",
      "valueReference": 1711276045,
      "causality": "local",
      "variability": "discrete",
      "type": "real",
      "unit": "1",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "1",
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      ],
      "start": 0
    },
    {
      "name": "rBC.draw_check",
      "description": "How often a new draw (a rise of blood_drawn) is looked for",
      "valueReference": 16777286,
      "causality": "parameter",
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      "type": "real",
      "unit": "s",
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        {
          "unit": "s",
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        {
          "unit": "min",
          "displayFactor": 0.016666666666666666,
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      ],
      "start": 60
    },
    {
      "name": "hepcidin.il6",
      "valueReference": 33554450,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "g",
      "displayFactor": 1000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg",
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        {
          "unit": "g",
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          "unit": "ug",
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      ],
      "min": 0,
      "nominal": 0.001
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    {
      "name": "hepcidin.Bmp6",
      "valueReference": 33554454,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "g",
      "displayFactor": 1000,
      "displayOffset": 0,
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        {
          "unit": "kg",
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        {
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      ],
      "min": 0,
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    },
    {
      "name": "hepcidin.ERFE",
      "description": "Erythroferrone, relative: 1 = normal",
      "valueReference": 33554453,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
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    {
      "name": "hepcidin.ERFE_regulation",
      "description": "Erythroferrone lowers hepcidin: 1 - yes, 0 - no",
      "valueReference": 16777287,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
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      "unitOptions": [],
      "start": 1
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    {
      "name": "hepcidin.K_ERFE",
      "description": "Erythroferrone (1 = normal) at which half of BMP6 is bound",
      "valueReference": 16777288,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "displayFactor": 1,
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      "unitOptions": [],
      "start": 2
    },
    {
      "name": "hepcidin.h_ERFE",
      "description": "Steepness of the binding",
      "valueReference": 16777289,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1",
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      "unitOptions": [
        {
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      ],
      "start": 2
    },
    {
      "name": "hepcidin.Bmp6_free_share",
      "description": "Share of BMP6 not bound by erythroferrone, 1 = normal",
      "valueReference": 1174405182,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "displayFactor": 1,
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      "unitOptions": []
    },
    {
      "name": "hepcidin.hep",
      "description": "Hepcidin amount (s16)",
      "valueReference": 33554449,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug",
      "displayFactor": 1000000000,
      "displayOffset": 0,
      "unitOptions": [
        {
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        {
          "unit": "g",
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        {
          "unit": "ug",
          "displayFactor": 1000000000,
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      ],
      "min": 0,
      "nominal": 0.001,
      "start": 6.649380000000001e-10
    },
    {
      "name": "der(hepcidin.hep)",
      "description": "der(Hepcidin amount (s16))",
      "valueReference": 1124073489,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "kg/s",
      "displayFactor": 1,
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      "unitOptions": [
        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
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        },
        {
          "unit": "ug/h",
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      ]
    },
    {
      "name": "hepcidin.k_deg",
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      ],
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    {
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      "description": "Production of IL-6",
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      "name": "erythropoietin.Fe_RBC",
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      "description": "Erythropoietin, relative: 1 = normal",
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    {
      "name": "erythroferrone.EPO",
      "description": "Erythropoietin, relative: 1 = normal",
      "valueReference": 1174405141,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": []
    },
    {
      "name": "erythroferrone.Fe_bm",
      "description": "Fe amount in bone marrow (erythroblasts)",
      "valueReference": 33554447,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "g",
      "displayFactor": 1000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "g",
          "displayFactor": 1000,
          "displayOffset": 0
        },
        {
          "unit": "ug",
          "displayFactor": 1000000000,
          "displayOffset": 0
        }
      ],
      "min": 0,
      "nominal": 0.001
    },
    {
      "name": "erythroferrone.ERFE",
      "description": "Erythroferrone, relative: 1 = normal",
      "valueReference": 33554453,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": []
    },
    {
      "name": "der(erythroferrone.ERFE)",
      "description": "der(Erythroferrone, relative: 1 = normal)",
      "valueReference": 1124073493,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": []
    },
    {
      "name": "erythroferrone.Fe_bm_normal",
      "description": "Normal (steady-state) bone-marrow iron",
      "valueReference": 16777308,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "ug",
      "displayFactor": 1000000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "g",
          "displayFactor": 1000,
          "displayOffset": 0
        },
        {
          "unit": "ug",
          "displayFactor": 1000000000,
          "displayOffset": 0
        }
      ],
      "min": 0,
      "nominal": 0.001,
      "start": 6.315960400000001e-8
    },
    {
      "name": "erythroferrone.tau",
      "description": "Time constant of erythroferrone (4 h)",
      "valueReference": 16777309,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "min",
      "displayFactor": 0.016666666666666666,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "s",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "min",
          "displayFactor": 0.016666666666666666,
          "displayOffset": 0
        }
      ],
      "nominal": 60,
      "start": 14400
    },
    {
      "name": "bmp6.Bmp6",
      "description": "Bmp6 amount (s18)",
      "valueReference": 33554454,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "ug",
      "displayFactor": 1000000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "g",
          "displayFactor": 1000,
          "displayOffset": 0
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        {
          "unit": "ug",
          "displayFactor": 1000000000,
          "displayOffset": 0
        }
      ],
      "min": 0,
      "nominal": 0.001,
      "start": 1.58291e-8
    },
    {
      "name": "der(bmp6.Bmp6)",
      "description": "der(Bmp6 amount (s18))",
      "valueReference": 1124073494,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "kg/s",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
        },
        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
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      ]
    },
    {
      "name": "bmp6.Fe_liv",
      "description": "Fe amount in liver",
      "valueReference": 33554433,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "g",
      "displayFactor": 1000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "g",
          "displayFactor": 1000,
          "displayOffset": 0
        },
        {
          "unit": "ug",
          "displayFactor": 1000000000,
          "displayOffset": 0
        }
      ],
      "min": 0,
      "nominal": 0.001
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    {
      "name": "bmp6.Fe_ser",
      "description": "Fe amount in serum",
      "valueReference": 33554432,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "g",
      "displayFactor": 1000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "g",
          "displayFactor": 1000,
          "displayOffset": 0
        },
        {
          "unit": "ug",
          "displayFactor": 1000000000,
          "displayOffset": 0
        }
      ],
      "min": 0,
      "nominal": 0.001
    },
    {
      "name": "bmp6.Bmp6_in",
      "description": "Bmp6 production rate",
      "valueReference": 1174405189,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
          "displayFactor": 1,
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        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
        },
        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "bmp6.Bmp6_out",
      "description": "Bmp6 production rate",
      "valueReference": 1174405190,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
        },
        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "bmp6.v_max",
      "description": "Bmp6 maximal synthesis rate",
      "valueReference": 100663308,
      "causality": "local",
      "variability": "tunable",
      "type": "real",
      "unit": "1/min",
      "displayFactor": 60,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "Hz",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "1/min",
          "displayFactor": 60,
          "displayOffset": 0
        },
        {
          "unit": "h-1",
          "displayFactor": 3600,
          "displayOffset": 0
        }
      ]
    },
    {
      "name": "bmp6.Tf",
      "description": "Paremeter determining the maximal amount of iron that can be bound to transferrin (k32)",
      "valueReference": 16777310,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "g",
      "displayFactor": 1000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "g",
          "displayFactor": 1000,
          "displayOffset": 0
        },
        {
          "unit": "ug",
          "displayFactor": 1000000000,
          "displayOffset": 0
        }
      ],
      "min": 0,
      "nominal": 0.001,
      "start": 0.0000010000000000000002
    },
    {
      "name": "bmp6.K",
      "description": "Michaelis-Menten constant Bmp6 synthesis (k37), 16.5/55.7",
      "valueReference": 16777311,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "g",
      "displayFactor": 1000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg",
          "displayFactor": 1,
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        {
          "unit": "g",
          "displayFactor": 1000,
          "displayOffset": 0
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        {
          "unit": "ug",
          "displayFactor": 1000000000,
          "displayOffset": 0
        }
      ],
      "min": 0,
      "nominal": 0.001,
      "start": 1.965e-8
    },
    {
      "name": "bmp6.k_max",
      "valueReference": 16777312,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1/(ug.h)",
      "displayFactor": 0.0000036000000000000003,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "1/(kg.s)",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "1/(ug.h)",
          "displayFactor": 0.0000036000000000000003,
          "displayOffset": 0
        }
      ],
      "start": 444861.1111111111
    },
    {
      "name": "bmp6.k_deg",
      "description": "Bmp6 degradation rate (k22), 1.0/9.5",
      "valueReference": 16777313,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1/min",
      "displayFactor": 60,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "Hz",
          "displayFactor": 1,
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        {
          "unit": "1/min",
          "displayFactor": 60,
          "displayOffset": 0
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        {
          "unit": "h-1",
          "displayFactor": 3600,
          "displayOffset": 0
        }
      ],
      "start": 0.0006656111111111111
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    {
      "name": "transfusion.k",
      "description": "Constant MassFlowRate output value",
      "valueReference": 16777314,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "ug.h-1",
      "displayFactor": 3600000000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
          "displayFactor": 60000000,
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8,
      "start": 0
    },
    {
      "name": "transfusion.y",
      "description": "MassFlowRate constant",
      "valueReference": 234881122,
      "causality": "local",
      "variability": "tunable",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
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        },
        {
          "unit": "mg/min",
          "displayFactor": 60000000,
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
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          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "bleeding.k",
      "description": "Constant MassFlowRate output value",
      "valueReference": 16777315,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "ug.h-1",
      "displayFactor": 3600000000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
          "displayFactor": 60000000,
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8,
      "start": 0
    },
    {
      "name": "bleeding.y",
      "description": "MassFlowRate constant",
      "valueReference": 234881123,
      "causality": "local",
      "variability": "tunable",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
          "displayFactor": 60000000,
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        {
          "unit": "ug.h-1",
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          "displayOffset": 0
        },
        {
          "unit": "ug/h",
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          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8
    },
    {
      "name": "Fe_food.k",
      "description": "Constant MassFlowRate output value",
      "valueReference": 16777316,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "ug.h-1",
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      "unitOptions": [
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          "unit": "kg/s",
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        {
          "unit": "mg/min",
          "displayFactor": 60000000,
          "displayOffset": 0
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
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      ],
      "nominal": 1.6666666666666667e-8,
      "start": 6.0731166666667e-11
    },
    {
      "name": "Fe_food.y",
      "description": "MassFlowRate constant",
      "valueReference": 234881124,
      "causality": "local",
      "variability": "tunable",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
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          "displayOffset": 0
        },
        {
          "unit": "ug/h",
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          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8
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    {
      "name": "Infusion.k",
      "description": "Constant MassFlowRate output value",
      "valueReference": 16777317,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "ug.h-1",
      "displayFactor": 3600000000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
          "displayFactor": 60000000,
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        {
          "unit": "ug.h-1",
          "displayFactor": 3600000000000,
          "displayOffset": 0
        },
        {
          "unit": "ug/h",
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          "displayOffset": 0
        }
      ],
      "nominal": 1.6666666666666667e-8,
      "start": 0
    },
    {
      "name": "Infusion.y",
      "description": "MassFlowRate constant",
      "valueReference": 234881125,
      "causality": "local",
      "variability": "tunable",
      "type": "real",
      "unit": "mg/min",
      "displayFactor": 60000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "kg/s",
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        {
          "unit": "mg/min",
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        {
          "unit": "ug.h-1",
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          "displayOffset": 0
        },
        {
          "unit": "ug/h",
          "displayFactor": 3600000000000,
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      ],
      "nominal": 1.6666666666666667e-8
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  ]
}