{
  "fmiVersion": "2.0",
  "modelName": "EnterocyteMucosalBlock.models.FerritinIronStorage",
  "modelIdentifier": "EnterocyteMucosalBlock_models_FerritinIronStorage",
  "guid": "{ad04c11d-5baf-437f-850c-9c35cf7f64a9}",
  "generationTool": "Dymola Version 2025x Refresh 1, 2025-04-11 (Co-simulation using Cvode)",
  "variables": [
    {
      "name": "Fe_total_set",
      "valueReference": 620756992,
      "causality": "input",
      "variability": "continuous",
      "type": "real",
      "unit": "mmol/l",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "mol/m3",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mmol/l",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mol/L",
          "displayFactor": 0.001,
          "displayOffset": 0
        }
      ],
      "min": 0,
      "start": 0
    },
    {
      "name": "Fe_in_FT",
      "valueReference": 603979776,
      "causality": "output",
      "variability": "continuous",
      "type": "real",
      "unit": "mmol/l",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "mol/m3",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mmol/l",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mol/L",
          "displayFactor": 0.001,
          "displayOffset": 0
        }
      ],
      "min": 0
    },
    {
      "name": "LIP",
      "valueReference": 603979777,
      "causality": "output",
      "variability": "continuous",
      "type": "real",
      "unit": "mmol/l",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "mol/m3",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mmol/l",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mol/L",
          "displayFactor": 0.001,
          "displayOffset": 0
        }
      ],
      "min": 0
    },
    {
      "name": "der(LIP)",
      "valueReference": 637534209,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "m-3.s-1.mol",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "m-3.s-1.mol",
          "displayFactor": 1,
          "displayOffset": 0
        }
      ]
    },
    {
      "name": "Fract_Fe_in_Ft",
      "valueReference": 603979778,
      "causality": "output",
      "variability": "continuous",
      "type": "real",
      "unit": "%",
      "displayFactor": 100,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "1",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "%",
          "displayFactor": 100,
          "displayOffset": 0
        }
      ],
      "nominal": 0.01
    },
    {
      "name": "Fract_LIP",
      "valueReference": 603979779,
      "causality": "output",
      "variability": "continuous",
      "type": "real",
      "unit": "%",
      "displayFactor": 100,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "1",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "%",
          "displayFactor": 100,
          "displayOffset": 0
        }
      ],
      "nominal": 0.01
    },
    {
      "name": "Fe_total",
      "valueReference": 637534210,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mmol/l",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "mol/m3",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mmol/l",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mol/L",
          "displayFactor": 0.001,
          "displayOffset": 0
        }
      ],
      "min": 0
    },
    {
      "name": "Fe_total_need",
      "valueReference": 637534211,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mmol/l",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "mol/m3",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mmol/l",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mol/L",
          "displayFactor": 0.001,
          "displayOffset": 0
        }
      ],
      "min": 0
    },
    {
      "name": "core",
      "description": "core",
      "valueReference": 33554432,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mmol/l",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "mol/m3",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mmol/l",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mol/L",
          "displayFactor": 0.001,
          "displayOffset": 0
        }
      ],
      "min": 0,
      "start": 0.007500000000000001
    },
    {
      "name": "der(core)",
      "description": "der(core)",
      "valueReference": 1124073472,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "m-3.s-1.mol",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "m-3.s-1.mol",
          "displayFactor": 1,
          "displayOffset": 0
        }
      ]
    },
    {
      "name": "DFP",
      "description": "diferric peroxo complex",
      "valueReference": 33554433,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mmol/l",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "mol/m3",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mmol/l",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mol/L",
          "displayFactor": 0.001,
          "displayOffset": 0
        }
      ],
      "min": 0,
      "start": 0
    },
    {
      "name": "der(DFP)",
      "description": "der(diferric peroxo complex)",
      "valueReference": 1124073473,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "m-3.s-1.mol",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "m-3.s-1.mol",
          "displayFactor": 1,
          "displayOffset": 0
        }
      ]
    },
    {
      "name": "atoms_per_cage_transient",
      "description": "Transient number of Fe atoms that are stored inside the core of a ferritin cage",
      "valueReference": 1174405124,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "1",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "1",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "%",
          "displayFactor": 100,
          "displayOffset": 0
        }
      ]
    },
    {
      "name": "H",
      "description": "H subunits",
      "valueReference": 16777216,
      "causality": "parameter",
      "variability": "tunable",
      "type": "integer",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [],
      "start": 4
    },
    {
      "name": "L",
      "description": "L subunits",
      "valueReference": 100663296,
      "causality": "local",
      "variability": "tunable",
      "type": "integer",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": []
    },
    {
      "name": "rN",
      "valueReference": 16777217,
      "causality": "parameter",
      "variability": "tunable",
      "type": "integer",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [],
      "start": 50
    },
    {
      "name": "rO",
      "valueReference": 16777218,
      "causality": "parameter",
      "variability": "tunable",
      "type": "integer",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [],
      "start": 2
    },
    {
      "name": "k_FTlysis",
      "valueReference": 16777219,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1/min",
      "displayFactor": 60,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "Hz",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "1/min",
          "displayFactor": 60,
          "displayOffset": 0
        }
      ],
      "start": 0.00001203
    },
    {
      "name": "k_Fe_total_set_achieve_time",
      "valueReference": 16777220,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1/min",
      "displayFactor": 60,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "Hz",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "1/min",
          "displayFactor": 60,
          "displayOffset": 0
        }
      ],
      "start": 0.01
    },
    {
      "name": "CoreRelease",
      "valueReference": 637534213,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mmol/(l.s)",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "mol/(m3.s)",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mmol/(l.s)",
          "displayFactor": 1,
          "displayOffset": 0
        }
      ]
    },
    {
      "name": "Oxidation",
      "valueReference": 637534214,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mmol/(l.s)",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "mol/(m3.s)",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mmol/(l.s)",
          "displayFactor": 1,
          "displayOffset": 0
        }
      ]
    },
    {
      "name": "k_cat_oxidation",
      "description": "catalytic turnover number",
      "valueReference": 16777221,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1/s",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "1/s",
          "displayFactor": 1,
          "displayOffset": 0
        }
      ],
      "start": 591
    },
    {
      "name": "K_m_oxidation",
      "description": "Michaelis constant",
      "valueReference": 16777222,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "mol/L",
      "displayFactor": 0.001,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "mol/m3",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mmol/l",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mol/L",
          "displayFactor": 0.001,
          "displayOffset": 0
        }
      ],
      "min": 0,
      "start": 0.35
    },
    {
      "name": "n_oxidation",
      "description": "Hill coefficient)",
      "valueReference": 16777223,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "1",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "%",
          "displayFactor": 100,
          "displayOffset": 0
        }
      ],
      "start": 1.3
    },
    {
      "name": "Reduction",
      "valueReference": 637534215,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mmol/(l.s)",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "mol/(m3.s)",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mmol/(l.s)",
          "displayFactor": 1,
          "displayOffset": 0
        }
      ]
    },
    {
      "name": "k_deg",
      "description": "rate constant",
      "valueReference": 16777224,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1/s",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "1/s",
          "displayFactor": 1,
          "displayOffset": 0
        }
      ],
      "start": 0.2605
    },
    {
      "name": "Nucleation",
      "valueReference": 1174405128,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mmol/(l.s)",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "mol/(m3.s)",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mmol/(l.s)",
          "displayFactor": 1,
          "displayOffset": 0
        }
      ]
    },
    {
      "name": "k_cat_nucleation",
      "description": "catalytic turnover number",
      "valueReference": 16777225,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "l2/(mol2.s)",
      "displayFactor": 1000000,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "m6/(mol2.s)",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "l2/(mol2.s)",
          "displayFactor": 1000000,
          "displayOffset": 0
        }
      ],
      "start": 50
    },
    {
      "name": "K_i_nucleation",
      "description": "inhibition constant",
      "valueReference": 16777226,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "mol/L",
      "displayFactor": 0.001,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "mol/m3",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mmol/l",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mol/L",
          "displayFactor": 0.001,
          "displayOffset": 0
        }
      ],
      "min": 0,
      "start": 0.461598
    },
    {
      "name": "n_nucleation",
      "description": "Hill coefficient",
      "valueReference": 16777227,
      "causality": "parameter",
      "variability": "tunable",
      "type": "integer",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [],
      "start": 4
    },
    {
      "name": "Mineralization",
      "valueReference": 1174405129,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "unit": "mmol/(l.s)",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "mol/(m3.s)",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mmol/(l.s)",
          "displayFactor": 1,
          "displayOffset": 0
        }
      ]
    },
    {
      "name": "k_cat_mineralization",
      "description": "catalytic turnover number",
      "valueReference": 16777228,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "1/s",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "1/s",
          "displayFactor": 1,
          "displayOffset": 0
        }
      ],
      "start": 0.101564
    },
    {
      "name": "K_m_mineralization",
      "description": "Michaelis constant",
      "valueReference": 16777229,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "mol/L",
      "displayFactor": 0.001,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "mol/m3",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mmol/l",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mol/L",
          "displayFactor": 0.001,
          "displayOffset": 0
        }
      ],
      "min": 0,
      "start": 0.005
    },
    {
      "name": "K_i_mineralization",
      "description": "inhibition constant",
      "valueReference": 16777230,
      "causality": "parameter",
      "variability": "tunable",
      "type": "real",
      "unit": "mol/L",
      "displayFactor": 0.001,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "mol/m3",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mmol/l",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mol/L",
          "displayFactor": 0.001,
          "displayOffset": 0
        }
      ],
      "min": 0,
      "start": 4.6458
    },
    {
      "name": "n_mineralization",
      "description": "Hill coefficient",
      "valueReference": 16777231,
      "causality": "parameter",
      "variability": "tunable",
      "type": "integer",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [],
      "start": 4
    },
    {
      "name": "m_mineralization",
      "description": "Hill coefficient",
      "valueReference": 16777232,
      "causality": "parameter",
      "variability": "tunable",
      "type": "integer",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [],
      "start": 8
    },
    {
      "name": "FT_cage",
      "valueReference": 620756993,
      "causality": "input",
      "variability": "continuous",
      "type": "real",
      "unit": "mmol/l",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [
        {
          "unit": "mol/m3",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mmol/l",
          "displayFactor": 1,
          "displayOffset": 0
        },
        {
          "unit": "mol/L",
          "displayFactor": 0.001,
          "displayOffset": 0
        }
      ],
      "min": 0,
      "start": 0.00003
    },
    {
      "name": "_StatesForOutputs.LIP",
      "description": "LIP",
      "valueReference": 33554434,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": [],
      "min": 0,
      "start": 0.000615243
    },
    {
      "name": "der(_StatesForOutputs.LIP)",
      "description": "der(LIP)",
      "valueReference": 587202562,
      "causality": "local",
      "variability": "continuous",
      "type": "real",
      "displayFactor": 1,
      "displayOffset": 0,
      "unitOptions": []
    }
  ]
}